In the article entitled "Clinical Effect of Rebound Hyperthermia After Cooling Postcardiac Arrest: A Meta-Analysis," (http://online.liebertpub.com/doi/full/10.1089/ther.2017.0009) coauthors Parth Makker, MD, Yumiko Kanei, MD, and Deepkia Misra, MD, Icahn School of Medicine, Mount Sinai Beth Israel, New York, NY, reviewed the results of studies published in the medical literature. These studies have produced conflicting results. The researchers performed a meta-analysis of multiple studies to gain a better understanding of the clinical significance of fever after therapeutic hypothermia treatment, which effects approximately half of patients.

"This timely publication is important because it emphasizes the potentially detrimental effects of rebound hyperthermia on neurological outcomes in survivors of cardiac arrest. This information should be taken into account during the rewarming phase of the hypothermic treatment," says W. Dalton Dietrich, III, PhD, Editor-in-Chief of Therapeutic Hypothermia and Temperature Management, Scientific Director of The Miami Project to Cure Paralysis, and Kinetic Concepts Distinguished Chair in Neurosurgery, University of Miami Leonard M. Miller School of Medicine.